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SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

12 Jan 2021

Abstract excerpt

dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins. Modulation of sirtuins can thus be utilized as a therapeutic target for metabolic disorders. Neurological diseases have distinct clinical manifestations but are mainly...

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PMID: 33597872
DOI: 10.3389/fphar.2020.585821

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