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Article

Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

9 Mar 2021

Abstract excerpt

Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer's patients. To understand SIRT6 roles in transcript pattern changes, we analyzed transcriptomes of young WT, old WT and young SIRT6-KO mice brains, and...

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PMID: 33690173
DOI: 10.18632/aging.202755

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