Article
Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.
Trends in molecular medicine - 1 Oct 2018
Madsen Ralitsa R, Vanhaesebroeck Bart, Semple Robert K
Abstract excerpt
PIK3CA is one of the most commonly mutated genes in solid cancers. PIK3CA mutations are also found in benign overgrowth syndromes, collectively known as PIK3CA-related overgrowth spectrum (PROS). As in cancer, PIK3CA mutations in PROS arise postzygotically, but unlike in cancer, these mutations arise during embryonic development, with their timing and location critically influencing the resulting disease...
Topics
- Carcinogenesis
- Cell Movement
- Cell Proliferation
- Class I Phosphatidylinositol 3-Kinases
- Embryo, Mammalian
- Embryonic Development
- Gene Expression Regulation, Neoplastic
- Genetic Association Studies
- Growth Disorders
- Humans
- Mutation