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Article

PIK3CA-related overgrowth: silver bullets from the cancer arsenal?

Trends in molecular medicine - 1 Apr 2022

Madsen Ralitsa R, Semple Robert K

Abstract excerpt

Mutations that activate growth factor signaling often drive cancer growth. Many also arise in isolation, causing developmental growth disorders. PIK3CA, that encodes a catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is a cardinal example of this paradigm. Recent exciting progress towards the key goal of cancer drug repurposing for PIK3CA-driven overgrowth is discussed.

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PMID: 35272946
DOI: 10.1016/j.molmed.2022.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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