Article
A pontine-specific axonal niche supports de novo gliomagenesis
2024-09-07
Abstract excerpt
Diffuse intrinsic pontine gliomas (DIPGs), a major type of pediatric high-grade gliomas located in the pons, are the leading cause of death in children with brain cancer. A subset (20-25%) of DIPGs harbor a lysine 27-to-methionine (K27M) mutation in HIST1H3B , which encodes histone H3.1, and an activating ACVR1 mutation. The occurrence of this pair of mutations in DIPGs, but not in pediatric gliomas in other ana...
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Identifiers and source
- Literature Corpus work
- 6c7ff78c-49ef-532c-8ebb-d4a8eb6d5d11
- DOI
- 10.1101/2024.09.04.611079