Article
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.
Science translational medicine - 23 Nov 2016
Bayliss Jill, Mukherjee Piali, Lu Chao, Jain Siddhant U, Chung Chan, Martinez Daniel, Sabari Benjamin, Margol Ashley S, Panwalkar Pooja, Parolia Abhijit, Pekmezci Melike, McEachin Richard C, Cieslik Marcin, Tamrazi Benita, Garcia Benjamin A, La Rocca Gaspare, Santi Mariarita, Lewis Peter W, Hawkins Cynthia, Melnick Ari, David Allis C, Thompson Craig B, Chinnaiyan Arul M, Judkins Alexander R, Venneti Sriram
Abstract excerpt
Childhood posterior fossa (PF) ependymomas cause substantial morbidity and mortality. These tumors lack recurrent genetic mutations, but a subset of these ependymomas exhibits CpG island (CpGi) hypermethylation [PF group A (PFA)], implicating epigenetic alterations in their pathogenesis. Further, histological grade does not reliably predict prognosis, highlighting the importance of developing more robust...
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