Article

Single-cell Mendelian randomisation identifies cell-type specific genetic effects on human brain disease and behaviour

2022-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Translating genome-wide association loci to therapies requires knowledge of the causal genes, their directionality of effect and the cell-types in which they act. To infer these relationships in the human brain, we implemented Mendelian randomisation using single cell-type expression quantitative trait loci (eQTLs) as genetic anchors. Expression QTLs were mapped across 8 major cell-types in brai...

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Literature Corpus work: 35dad177-ab79-5863-9c9c-26e671c601df
DOI: 10.1101/2022.11.28.517913

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