Article

Astroglial Dysfunction in Models of CDKL5 Deficiency Disorder

2026-06-10

Abstract excerpt

CDKL5 Deficiency Disorder (CDD) is a rare developmental epileptic encephalopathy typically caused by loss of function variants in the gene encoding the X-linked serine-threonine kinase CDKL5. CDKL5 is highly expressed in the brain during development, and key neuronal functions of the kinase include cytoskeletal organisation and synaptic stability. However, at present, little is known about the function of astrogli...

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Literature Corpus work: 572e1cd4-050e-53eb-9a75-587e25dec7f8
DOI: 10.64898/2026.06.09.730164

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