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Article

Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.

PLoS genetics - 1 Feb 2017

Zhu Jiuhe, Lee Kwan Young, Jewett Kathryn A, Man Heng-Ye, Chung Hee Jung, Tsai Nien-Pei

Abstract excerpt

The neural precursor cell expressed developmentally down-regulated gene 4-2, Nedd4-2, is an epilepsy-associated gene with at least three missense mutations identified in epileptic patients. Nedd4-2 encodes a ubiquitin E3 ligase that has high affinity toward binding and ubiquitinating membrane proteins. It is currently unknown how Nedd4-2 mediates neuronal circuit activity and how its dysfunction leads to seizures...

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Source

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Identifiers

PMID: 28212375
DOI: 10.1371/journal.pgen.1006634
PMCID: PMC5338825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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