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Article

LC3-associated endocytosis and the functions of Rubicon and ATG16L1

26 Oct 2022

Abstract excerpt

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway. LANDO was initially discovered in a murine model of Alzheimer's disease as a critical regulator of amyloid-β receptor recycling in microglial cells, playing a protective role...

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PMID: 36288306
DOI: 10.1126/sciadv.abo5600

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