Article

Identification of Region-Specific Gene Isoforms in the Human Brain Using Long-Read Transcriptome Sequencing and Their Correlation with DNA Methylation

2023-05-14

Abstract excerpt

<h4>Background</h4> Site specificity is known in neuropsychiatric disorders, and differences in gene expression patterns could potentially explain this mechanism. However, studies using long-read transcriptome sequencing to analyze gene expression in different regions of the human brain have been limited, and none have focused on the hypothalamus, which plays a crucial role in regulating autonomic functions. <h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35be7d05-7402-5f7f-8666-751c4397e33c
DOI: 10.1101/2023.05.13.540603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Region-Specific Gene Isoforms in the Human Brain Using Long-Read Transcriptome Sequencing and Their Correlation with DNA MethylationDOI 10.1101/2023.05.13.540603Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanismsSemantic proximity Read

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.Semantic proximity Read

Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brainSemantic proximity Read

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles.Semantic proximity Read

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortexSemantic proximity Read

Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and developmentSemantic proximity Read

Long-read transcriptomics of purified human cortical cell types exposes glial isoform complexity and disease-relevant transcript architectureSemantic proximity Read

Spatial transcriptomics identifies the molecular and disease landscapes of adult human hypothalamusSemantic proximity Read

Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usageSemantic proximity Read

Isoform-level profiling of m6A epitranscriptomic signatures in human brainSemantic proximity Read

Genetic regulation of lncRNA expression in the whole human brainSemantic proximity Read

The architecture of brain co-expression reveals the brain-wide basis of disease susceptibilitySemantic proximity Read