Article
RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles.
BMC genomics - 23 Nov 2015
Webb Amy, Papp Audrey C, Curtis Amanda, Newman Leslie C, Pietrzak Maciej, Seweryn Michal, Handelman Samuel K, Rempala Grzegorz A, Wang Daqing, Graziosa Erica, Tyndale Rachel F, Lerman Caryn, Kelsoe John R, Mash Deborah C, Sadee Wolfgang
Abstract excerpt
BACKGROUND: We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subjects. RNA sequencing techniques were designed to detect both coding and non-coding RNA, splice isoform composition, and allelic expression. Brain regions were selected from five subjects with a documented history of smoking and five non-smokers. Paired-end RNA sequencing was performed on SOLiD instruments...
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