Article

Genetic regulation of lncRNA expression in the whole human brain

2024-05-22

Abstract excerpt

Long non-coding RNAs (lncRNAs) play a key role in the human brain, and genetic variants regulate their expression. Herein, the expression quantitative trait loci (eQTL) of lncRNAs encompassing ten brain regions from 134 individuals was analyzed, and novel variants influencing lncRNA expression (eSNPs) and the respective affected lncRNAs (elncRNAs) were identified. The eSNPs are proximate to their corresponding eln...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77baa864-1479-559a-9abc-d8f24038a508
DOI: 10.1101/2024.05.20.594968

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic regulation of lncRNA expression in the whole human brainDOI 10.1101/2024.05.20.594968Read

Mapping the genetic regulation of long non-coding RNAs across cellular contexts advances understanding of complex brain diseasesSemantic proximity Read

Identification of lncRNAs differentially expressed in Alzheimer’s disease brains using RNA sequencingSemantic proximity Read

Genome-wide analysis of human SNPs at long intergenic noncoding RNAs.Semantic proximity Read

Frequent functional orthology of long noncoding RNAs and genomic loci associated with complex traits and disordersSemantic proximity Read

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.Semantic proximity Read

Emerging Roles of Long Non-Coding RNAs as Drivers of Brain EvolutionSemantic proximity Read

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles.Semantic proximity Read

A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Semantic proximity Read

Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological diseaseSemantic proximity Read

Genetic variability in the regulation of gene expression in ten regions of the human brain.Semantic proximity Read

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.Semantic proximity Read

Identification of Region-Specific Gene Isoforms in the Human Brain Using Long-Read Transcriptome Sequencing and Their Correlation with DNA MethylationSemantic proximity Read