Article

Genetic depletion of early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

2025-08-06

Abstract excerpt

<title>Abstract</title> <p> M1 macrophage activation is crucial in chronic inflammatory diseases, yet its molecular mechanism is unclear. Our study shows that hemizygous deletion of early autophagy gene <italic>atg13</italic> (Tg <sup>+/−</sup> ATG13) disrupts cellular autophagy, hinders mitochondrial oxidative metabolism, increases reactive oxygen species (ROS) in splenic macrophages, leading to its M1 pola...

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Literature Corpus work: f4bcd642-35d6-5dca-b6e6-6c4b6cecbe8b
DOI: 10.21203/rs.3.rs-7189456/v1

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