Article

Stroke-induced lipocalin-2-expressing red pulp macrophages reprogram peripheral immunity

2026-06-28

Abstract excerpt

Acute ischemic stroke (AIS) induces profound systemic immune alterations that contribute to infection susceptibility. Here, we identify lipocalin-2 (LCN-2) as a rapidly induced and conserved regulator of stroke-associated immunosuppression. Using 3’-MACE-Seq, cytokine profiling, and immunofluorescence in C57BL/6J mice subjected to transient middle cerebral artery occlusion (tMCAO), we show that LCN-2 is strongly u...

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Literature Corpus work: 9ca2cbfd-40b4-5ec8-8b05-2dbb84b162a3
DOI: 10.64898/2026.06.23.733904

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