Article

Small-molecule activators of a bacterial signaling pathway inhibit virulence

2023-12-02

Abstract excerpt

The Burkholderia genus encompasses multiple human pathogens, including potential bioterrorism agents, that are often extensively antibiotic resistant. The FixLJ pathway in Burkholderia is a two-component system that regulates virulence. Previous work showed that fixLJ mutations arising during chronic infection confer increased virulence while decreasing the activity of the FixLJ pathway. We hypothesized that sm...

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Literature Corpus work: 35a88999-30bb-5256-986e-ed196090ffce
DOI: 10.1101/2023.12.02.569726

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