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Computer-Aided Design of Agents That Inhibit the <i>cep</i> Quorum-Sensing System of <i>Burkholderia cenocepacia</i>

23 Dec 2005

Abstract excerpt

Recent research has provided evidence that interference with bacterial cell-to-cell signaling is a promising strategy for the development of novel antimicrobial agents. Here we report on the computer-aided design of novel compounds that specifically inhibit an N-acyl-homoserine lactone-dependent communication system that is widespread among members of the genus Burkholderia. This genus comprises more than 30...

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PMID: 16377703
DOI: 10.1128/aac.50.1.318-323.2006

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