Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution towards Virulence in a Burkholderia Two-Component System.

mBio - 31 Aug 2021

Schaefers Matthew M, Wang Benjamin X, Boisvert Nicole M, Martini Sarah J, Bonney Sarah L, Marshall Christopher W, Laub Michael T, Cooper Vaughn S, Priebe Gregory P

Abstract excerpt

Bacteria in the Burkholderia cepacia complex (BCC) are significant pathogens for people with cystic fibrosis (CF) and are often extensively antibiotic resistant. Here, we assess the impacts of clinically observed mutations in fixL, which encodes the sensor histidine kinase FixL. FixL along with FixJ compose a two-component system that regulates multiple phenotypes. Mutations in fixL across two species, B. dolosa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Burkholderia
Share to Burkholderia cepacia complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Burkholderia Infections

Share to Histidine Kinase

Share to Macrophages

Share to Pneumonia

Share to THP-1 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34372701
DOI: 10.1128/mBio.01823-21
PMCID: PMC8406202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution towards Virulence in a Burkholderia Two-Component System.PMID 34372701Read ↗

Host adaptations in the <i>fixLJ</i> pathway of the <i>Burkholderia cepacia</i> complex increase virulenceSemantic proximity Read ↗

An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and PathogenicitySemantic proximity Read ↗

Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient LungSemantic proximity Read ↗

Within-Host Evolution of Burkholderia pseudomallei during Chronic Infection of Seven Australasian Cystic Fibrosis PatientsSemantic proximity Read ↗

Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence.Semantic proximity Read ↗

<i>De novo</i> mutations mediate phenotypic switching in an opportunistic human lung pathogenSemantic proximity Read ↗

Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.Semantic proximity Read ↗

Taxonomy and pathogenesis of the Burkholderia cepacia complexSemantic proximity Read ↗

A Decade of <i>Burkholderia cenocepacia</i> Virulence Determinant ResearchSemantic proximity Read ↗

Adaptation and Evolution of Pathogens in the Cystic Fibrosis LungSemantic proximity Read ↗

Within-host evolution of Burkholderia pseudomallei over a twelve-year chronic carriage infection.Semantic proximity Read ↗

Co-evolutionary signals from <i>Burkholderia pseudomallei</i> genomics identify its survival strategies and highlight improving environmental health as prevention policySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.