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Article

The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.

Antimicrobial agents and chemotherapy - 1 Jan 2014

Cummings Jason E, Kingry Luke C, Rholl Drew A, Schweizer Herbert P, Tonge Peter J, Slayden Richard A

Abstract excerpt

The bacterial fatty acid biosynthesis pathway is a validated target for the development of novel chemotherapeutics. However, since Burkholderia pseudomallei carries genes that encode both FabI and FabV enoyl-acyl carrier protein (ACP) reductase homologues, the enoyl-ACP reductase that is essential for in vivo growth needs to be defined so that the correct drug target can be chosen for development. Accordingly,...

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Identifiers

PMID: 24277048
DOI: 10.1128/AAC.00176-13
PMCID: PMC3910854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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