Article

Host adaptations in the <i>fixLJ</i> pathway of the <i>Burkholderia cepacia</i> complex increase virulence

2020-05-05

Abstract excerpt

The Burkholderia cepacia complex (BCC) is composed of multiple species, including B. multivorans and B. dolosa, that are significant pathogens for people with cystic fibrosis (CF) and are extensively resistant to many antibiotics. The fixL gene of the fixLJ 2-component system (TCS) in these BCC species shows evidence of positive selection for nonsynonymous mutations during chronic lung infection in CF. Previo...

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Literature Corpus work: 6f7f0e3b-6379-5463-9f1e-3cdd96a60d9a
DOI: 10.1101/2020.05.04.070367

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