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Communication Systems in the Genus Burkholderia : Global Regulators and Targets for Novel Antipathogenic Drugs

1 Oct 2007

Abstract excerpt

The genus Burkholderia not only contains the primary pathogens Burkholderia pseudomallei and Burkholderia mallei but also several species that have emerged as opportunistic pathogens in persons suffering from cystic fibrosis or chronic granulomatous disease and immunocompromised individuals. Burkholderia species utilize quorum-sensing (QS) systems that rely on N-acyl-homoserine lactone (AHL) signal molecules to...

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PMID: 17927476
DOI: 10.2217/17460913.2.5.555

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