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Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms

4 Mar 2015

Abstract excerpt

Burkholderia pathogenicity relies on protein virulence factors to control and promote bacterial internalization, survival, and replication within eukaryotic host cells. We recently used yeast two-hybrid (Y2H) screening to identify a small set of novel Burkholderia proteins that were shown to attenuate disease progression in an aerosol infection animal model using the virulent Burkholderia mallei ATCC 23344...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25738731
DOI: 10.1371/journal.pcbi.1004088

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