A Generalization of the Ternary Binding Model to Membrane-Confined Systems with Finite Copy Number

Abstract excerpt

Bispecific T cell engagers and related immunotherapies are dosed using equilibrium binding models derived for well-mixed solution, yet therapeutic activity occurs at nanoscale membrane synapses with finite receptor copy numbers. Here we show that membrane confinement introduces geometry-dependent corrections to the landmark Douglass [6] ternary binding model, shifting formation half-points ( TF 50 ) by 2–10-fold...

Topics

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• CAR-T cell therapy research
• HIV Research and Treatment
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• Nanowire Synthesis and Applications
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

2032a0ce-b722-54b1-a97d-1c6c26f966b9

DOI

10.64898/2026.04.10.717668