Article

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates

2023-02-15

Abstract excerpt

Immunoglobulin (Ig)G antibodies coordinate immune effector responses by selectively binding to target antigens and then interacting with various effector cells via the Fcγ receptors. The Fc domain of IgG can promote or inhibit distinct effector responses across several different immune cell types through variation based on subclass and Fc domain glycosylation. Extensive characterization of these interactions has r...

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Literature Corpus work: cd708e5b-b43a-5565-8a45-7af783709e8b
DOI: 10.1101/2023.02.15.528730

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