Article

Ph+B-ALL is defined by BCR::ABL1-induced enhancer reprogramming and hypersensitivity to enhancer-targeting drugs

2025-06-09

Abstract excerpt

<title>Abstract</title> <p>Cancer is driven by genomic lesions and malignancy-promoting transcriptional programs. In blood cancers, both are often directly linked as lesions frequently affect transcription factor (TF) or epigenetic co-factor-encoding genes. Transcriptional regulation is largely mediated through ‘enhancers’ and their deregulation repeatedly linked to cancer initiation and progression. Consequently...

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Literature Corpus work: 3565fba0-d97e-5db3-9379-352043fb8260
DOI: 10.21203/rs.3.rs-6757036/v1

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