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Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy

2025-07-11

Abstract excerpt

<h4>Summary</h4> Despite therapeutic advances, high-risk subtypes of B-cell acute lymphoblastic leukemia (B-ALL) such as Philadelphia chromosome-like (Ph-like) and KMT2A -rearranged ( KMT2A -R) remain a formidable clinical challenge. BRG1 (gene name SMARCA4 ), the ATPase subunit of the SWI/SNF chromatin-remodeling complex, has been extensively studied in solid tumors, where inactivating mutations are linked to...

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Identifiers and source

Literature Corpus work
c8aa569a-0599-52f6-92d9-3c59be254ba2
DOI
10.1101/2025.07.08.661805
Open publication

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Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy StrategyDOI 10.1101/2025.07.08.661805
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