Article
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
Cancer cell - 14 Aug 2012
Roberts Kathryn G, Morin Ryan D, Zhang Jinghui, Hirst Martin, Zhao Yongjun, Su Xiaoping, Chen Shann-Ching, Payne-Turner Debbie, Churchman Michelle L, Harvey Richard C, Chen Xiang, Kasap Corynn, Yan Chunhua, Becksfort Jared, Finney Richard P, Teachey David T, Maude Shannon L, Tse Kane, Moore Richard, Jones Steven, Mungall Karen, Birol Inanc, Edmonson Michael N, Hu Ying, Buetow Kenneth E, Chen I-Ming, Carroll William L, Wei Lei, Ma Jing, Kleppe Maria, Levine Ross L, Garcia-Manero Guillermo, Larsen Eric, Shah Neil P, Devidas Meenakshi, Reaman Gregory, Smith Malcolm, Paugh Steven W, Evans William E, Grupp Stephan A, Jeha Sima, Pui Ching-Hon, Gerhard Daniela S, Downing James R, Willman Cheryl L, Loh Mignon, Hunger Stephen P, Marra Marco A, Mullighan Charles G
Abstract excerpt
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1-positive ALL and poor outcome (Ph-like ALL). The genetic alterations that activate kinase signaling in Ph-like ALL are poorly understood. We performed transcriptome and whole genome sequencing on 15 cases of Ph-like ALL and identified...
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