Article
The biology of Philadelphia chromosome-like ALL.
Best practice & research. Clinical haematology - 1 Sept 2017
Roberts Kathryn G
Abstract excerpt
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a recently described subtype of B-cell precursor ALL with a gene expression profile similar to Ph-positive ALL and a high frequency of IKZF1 alterations. The prevalence of Ph-like ALL increases with age, ranging from 10-15% of children to over 25% of young adults with ALL. It occurs more frequently in males and is associated with adverse...
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