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Article

IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.

Blood - 20 Aug 2026

Bendig Sonja, Hartmann Alina M, Wessels Wiebke, Beder Thomas, Kim Rathana, Passet Marie, Gao Qingsong, Wolgast Nadine, Horns Johanna M, Santos Leonardo Alves, Iben Katharina, Steffen Fabio D, Cantoni Loredana, Kehden Britta, Chitadze Guranda, Künstner Axel, Busch Hauke, Bornhauser Beat, Bourquin Jean-Pierre, Leguay Thibaut, Boissel Nicolas, Gökbuget Nicola, Iacobucci Ilaria, Mullighan Charles G, Clappier Emmanuelle, Baldus Claudia D, Brüggemann Monika, Bastian Lorenz

Abstract excerpt

ABSTRACT: Large-scale sequencing efforts have defined up to 27 diagnostic subtypes in B-cell precursor acute lymphoblastic leukemia (B-ALL), leaving few samples unclassified. Extended genomic and transcriptomic profiling in routine diagnostics broadens the sample collection, enabling identification of novel subtypes. We analyzed 4857 patients with B-ALL from 3 cohorts and identified a group of 20 patients (age,...

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RNA, Long Noncoding
Adolescent
Aged
Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 41894249
DOI: 10.1182/blood.2025031102
PMCID: PMC13072441

Genes

FOXF1
IGH
KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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