Article

Unraveling BCR::ABL1-driven enhancer activation and transcriptional reprogramming in Ph B-ALL

2024-10-25

Abstract excerpt

<title>Abstract</title> <p>B-lineage acute-lymphoblastic leukemia (B-ALL) is driven by genomic lesions and distinct transcriptional programs. Both are often directly linked as most B-ALLs are caused by genetic lesions at transcription factor (TF)-encoding genes. TFs largely mediate their function through gene regulatory ‘enhancer’ elements and enhancer deregulation is known to promote cancer initiation and progre...

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Literature Corpus work: a8bd1912-c759-58fb-b55d-60f898407a2a
DOI: 10.21203/rs.3.rs-5326686/v1

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