Article

Identification of HCN1 as a 14-3-3 client

2021-08-19

Abstract excerpt

Hyperpolarization activated cyclic nucleotide-gated channel 1 (HCN1) is expressed throughout the nervous system and is critical for regulating neuronal excitability, with mutations being associated with multiple forms of epilepsy. Adaptive modulation of HCN1 has been observed as has pathogenic dysregulation. While the mechanisms underlying this modulation remain incompletely understood, regulation of HCN1 has been...

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Literature Corpus work: 35648dd6-bfa7-53b1-b5a4-c1e8700b5e94
DOI: 10.1101/2021.08.19.457009

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