Article
Molecular basis for plasma membrane recruitment of PI4KA by EFR3.
Science advances - 20 Dec 2024
Suresh Sushant, Shaw Alexandria L, Pemberton Joshua G, Scott Mackenzie K, Harris Noah J, Parson Matthew A H, Jenkins Meredith L, Rohilla Pooja, Alvarez-Prats Alejandro, Balla Tamas, Yip Calvin K, Burke John E
Abstract excerpt
The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7 and FAM126. Fundamental to PI4KA activity is its targeted recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B. Here, we report a cryogenic electron...
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