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Article

Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4.

Biochemistry - 25 Nov 2008

Ye Bin, Balijepalli Ravi C, Foell Jason D, Kroboth Stacie, Ye Qi, Luo Yu-Hong, Shi Nian-Qing

Abstract excerpt

Targeting of ion channels to caveolae, a subset of lipid rafts, allow cells to respond efficiently to extracellular signals. Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) 4 is a major subunit for the cardiac pacemaker. Caveolin-3 (Cav3), abundantly expressed in muscle cells, is responsible for forming caveolae. P104L, a Cav3 mutant, has a dominant negative effect on wild type (WT) Cav3 and...

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Share to Caveolin 3
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

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Source

Open in PubMed Open full text

Identifiers

PMID: 19238754
DOI: 10.1021/bi8009295
PMCID: PMC2803323

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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