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Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases.

Chembiochem : a European journal of chemical biology - 5 Jan 2021

Chiki Anass, Ricci Jonathan, Hegde Ramanath, Abriata Luciano A, Reif Andreas, Boudeffa Driss, Lashuel Hilal A

Abstract excerpt

Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the Huntingtin protein (Httex1) play important roles in modulating its cellular properties and functions in health and disease. In particular, phosphorylation of threonine and serine residues (T3, S13, and/or S16) has been shown to inhibit Htt aggregation in vitro and inclusion formation in cellular and animal models of...

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Exons
Huntingtin Protein
Mutation
Phosphorylation
Phosphotransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Aggregates

Protein Conformation

Recombinant Proteins

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PMID: 32805086
DOI: 10.1002/cbic.202000508
PMCID: PMC8698011

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