Article
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
The Journal of biological chemistry - 12 Oct 2018
Sierra-Valdez Francisco, Azumaya Caleigh M, Romero Luis O, Nakagawa Terunaga, Cordero-Morales Julio F
Abstract excerpt
The transient receptor potential ion channels support Ca2+ permeation in many organs, including the heart, brain, and kidney. Genetic mutations in transient receptor potential cation channel subfamily C member 3 (TRPC3) are associated with neurodegenerative diseases, memory loss, and hypertension. To better understand the conformational changes that regulate TRPC3 function, we solved the cryo-EM structures for...
Topics
- Allosteric Regulation
- Ankyrin Repeat
- HEK293 Cells
- Humans
- Ion Channel Gating
- Mutation
- Protein Conformation, alpha-Helical
- Protein Domains
- TRPC Cation Channels