Article
A pH-Mediated Topological Switch within the N-Terminal Domain of Human Caveolin-3.
Biophysical journal - 7 Jun 2016
Kim Ji-Hun, Schlebach Jonathan P, Lu Zhenwei, Peng Dungeng, Reasoner Kaitlyn C, Sanders Charles R
Abstract excerpt
Caveolins mediate the formation of caveolae, which are small omega-shaped membrane invaginations involved in a variety of cellular processes. There are three caveolin isoforms, the third of which (Cav3) is expressed in smooth and skeletal muscles. Mutations in Cav3 cause a variety of human muscular diseases. In this work, we characterize the secondary structure, dynamics, and topology of the monomeric form of the...
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