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Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein–Protein Interactions

9 Nov 2015

Abstract excerpt

Giardiasis is a gastrointestinal diarrheal illness caused by the protozoan parasite Giardia duodenalis, which affects annually over 200 million people worldwide. The limited antigiardial drug arsenal and the emergence of clinical cases refractory to standard treatments dictate the need for new chemotherapeutics. The 14-3-3 family of regulatory proteins, extensively involved in protein-protein interactions (PPIs)...

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PMID: 26551337
DOI: 10.1021/acs.jcim.5b00452

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