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The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS <sup>hi</sup> GITR <sup>hi</sup> Blimp-1 <sup>+</sup> effector regulatory T cells in breast tumors

2022-10-05

Abstract excerpt

While essential gatekeepers of immune homeostasis, Foxp3 + regulatory T (T reg ) cells infiltrating tumors acquire distinct phenotypes and become highly immunosuppressive, promoting tumor immune escape and growth. How this occurs and relates to tumor-driver mutations is largely uncharacterized. Herein, we created a mouse mammary stem cell-based tumor model using CRISPR gene editing in which we introduced known h...

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Literature Corpus work
30428efe-e064-5d02-b619-0990dd3b15c3
DOI
10.1101/2022.10.02.510540
Open publication

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The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS <sup>hi</sup> GITR <sup>hi</sup> Blimp-1 <sup>+</sup> effector regulatory T cells in breast tumorsDOI 10.1101/2022.10.02.510540
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