Article

Mutant TP53 Hotspot Variants Differentially Rewire the Caspase Regulatory Network Across Cancer Lineages: A Pan-Cancer Computational Pharmacology Analysis

2026-04-06

Abstract excerpt

<title>Abstract</title> Background TP53 is mutated in approximately 50% of all human cancers, and mutant p53 (mutp53) proteins acquire gain-of-function (GOF) activities that actively suppress apoptosis. However, the mechanism by which mutp53 specifically rewires the complete caspase regulatory network spanning initiator caspases, executioner caspases, the PIDDosome complex, the pseudo-caspase FLIP (CFLAR), inh...

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Literature Corpus work: e726bef1-aa3d-59d8-b2db-d67a9f9a9b31
DOI: 10.21203/rs.3.rs-9309751/v1

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