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Article

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma.

Journal for immunotherapy of cancer - 1 Aug 2023

Shi Yewen, Ren Xiaoyong, Cao Shaolong, Chen Xi, Yuan Bo, Brasil da Costa Fabio Henrique, Rodriguez Rosario Alanis E, Corona Arnoldo, Michikawa Chieko, Veeramachaneni Ratna, Osman Abdullah A, Xie Tongxin, Wang Wenyi, Sikora Andrew G, Myers Jeffrey N, Rangel Roberto

Abstract excerpt

BACKGROUND: TP53, the most mutated gene in solid cancers, has a profound impact on most hallmarks of cancer. Somatic TP53 mutations occur in high frequencies in head and neck cancers, including oral squamous cell carcinoma (OSCC). Our study aims to understand the role of TP53 gain-of-function mutation in modulating the tumor immune microenvironment (TIME) in OSCC. METHODS: Short hairpin RNA knockdown of mutant...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gain of Function Mutation

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Source

Open in PubMed Open full text

Identifiers

PMID: 37604640
DOI: 10.1136/jitc-2023-006666
PMCID: PMC10445354

Genes

TP53
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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