Article

MAPK ERK5 Is a Novel Regulator of MHC-I in Cancer Cells

2026-02-11

Abstract excerpt

Downregulation of major histocompatibility complex class I (MHC-I) molecules is a frequent mechanism of tumor immune evasion, impairing recognition and elimination of cancer cells by cytotoxic CD8 + T lymphocytes. This phenotype, associated with poor prognosis and resistance to immune checkpoint blockade, is often driven by oncogenic pathways that reversibly suppress MHC-I. The MAPK ERK5 and its only upstream act...

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Literature Corpus work: 352f99cc-2d74-57b0-806e-1bcea3fc8968
DOI: 10.64898/2026.02.10.705047

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