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Article

Oncogenic signaling of MEK5-ERK5.

Cancer letters - 28 Apr 2017

Hoang Van T, Yan Thomas J, Cavanaugh Jane E, Flaherty Patrick T, Beckman Barbara S, Burow Matthew E

Abstract excerpt

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MEK5 pathway has only recently emerged in cancer research. In this review, we consider the MEK5 signaling cascade, focusing specifically on its involvement in drug resistance and...

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Identifiers

PMID: 28153789
DOI: 10.1016/j.canlet.2017.01.034
PMCID: PMC5901897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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