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Article

The MNK1/2-eIF4E axis drives melanoma plasticity, progression, and resistance to immunotherapy

2020-05-30

Abstract excerpt

Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state. Melanoma plasticity exhibited as phenotype switching contributes to immunotherapy resistance, however the mechanisms are not completely understood and thus therapeutically unexploited. Here, using a transgenic melanoma mouse model, we demonstrated a critical role of the MNK1/2-eIF4E axis in melanoma plasticity and resistance...

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Literature Corpus work
e2001e6e-20a8-5624-90d0-e48cd92dbb93
DOI
10.1101/2020.05.29.117531
Open publication

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The MNK1/2-eIF4E axis drives melanoma plasticity, progression, and resistance to immunotherapyDOI 10.1101/2020.05.29.117531
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