Article

Genome-wide Screens Identify Lineage- and Tumor Specific-Genes Modulating MHC-I and MHC-II Immunosurveillance in Human Lymphomas

2020-03-14

Abstract excerpt

<h4>Summary</h4> Tumors frequently subvert MHC class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance. To better define the regulatory networks controlling antigen presentation, we employed genome-wide screening in human diffuse large B cell lymphomas (DLBCLs). This approach revealed dozens of novel genes that positively and negatively modulate MHC-I cell surface levels. Identified genes clu...

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Literature Corpus work: 14e22980-b893-5cc3-a463-bd01e541e8b9
DOI: 10.1101/2020.03.13.989558

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