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Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

28 Sept 2016

Abstract excerpt

T cells. The regulation of MHC-I by kinases is largely unstudied, even though many patients with cancer are receiving therapeutic kinase inhibitors. Regulators of cell-surface HLA amounts were discovered using a pooled human kinome shRNA interference-based approach. Hits scoring highly were subsequently validated by additional RNAi and pharmacologic inhibitors. MAP2K1 (MEK), EGFR, and RET were validated as...

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PMID: 27680026
DOI: 10.1158/2326-6066.cir-16-0177

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