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Article

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.

Cancer immunology research - 1 Jun 2015

Bradley Sherille D, Chen Zeming, Melendez Brenda, Talukder Amjad, Khalili Jahan S, Rodriguez-Cruz Tania, Liu Shujuan, Whittington Mayra, Deng Wanleng, Li Fenge, Bernatchez Chantale, Radvanyi Laszlo G, Davies Michael A, Hwu Patrick, Lizée Gregory

Abstract excerpt

Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune suppression within the tumor microenvironment. We show here that BRAF(V600E) also induces rapid internalization of...

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Topics

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Share to Antigen Presentation
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Immunophenotyping

Share to MAP Kinase Signaling System

Share to Melanoma

Share to Protein Interaction Domains and Motifs

Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 25795007
DOI: 10.1158/2326-6066.CIR-15-0030
PMCID: PMC4457616

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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