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Loss of essential outer membrane functions causes drug hypersensitization in <i>Acinetobacter baumannii</i> overexpressing multidrug efflux pumps

2024-01-05

Abstract excerpt

Elevated expression of Resistance-Nodulation-Cell Division (RND) drug transporters is commonly observed in clinical isolates of Acinetobacter baumannii , a nosocomial pathogen associated with multidrug-resistant (MDR) infections. We describe here a CRISPRi platform directed toward identifying essential gene hypomorphs that preferentially change resistance to the fluoroquinolone antibiotic ciprofloxacin in RND pum...

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Identifiers and source

Literature Corpus work
c0678694-54dd-5d95-91ec-3b8e37486bd6
DOI
10.1101/2024.01.04.574119
Open publication

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