Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression.

Atherosclerosis - 1 May 2020

Wang Qiang, Chen Ken, Zhang Fan, Peng Ke, Wang Zhen, Yang Dachun, Yang Yongjian

Abstract excerpt

BACKGROUND AND AIMS: TRPA1 is a calcium permeable non-selective cation channel, its expression is up-regulated in atherosclerosis plaque, yet its function in macrophages activation is unknown. We sought to establish the role of TRPA1 in inflammatory macrophages activation. METHODS: TRPA1-/-ApoE-/- mice and C57BL/6 J control were treated with a high-fat diet (HFD) and the TRPA1 agonist cinnamaldehyde (CIN)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Atherosclerosis
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Plaque, Atherosclerotic

Share to TRPA1 Cation Channel

Source

Identifiers

PMID: 32325260
DOI: 10.1016/j.atherosclerosis.2020.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression.PMID 32325260Read ↗

New Classification of Macrophages in Plaques: a Revolution.Semantic proximity Read ↗

Macrophage function in atherosclerosisSemantic proximity Read ↗

Regulation of Macrophage Activation and Differentiation in AtherosclerosisSemantic proximity Read ↗

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.Semantic proximity Read ↗

miR487a-3p and miR6855-3p Facilitate Macrophage Pro-inflammatory Polarization and Lipid Accumulation in AtherosclerosisSemantic proximity Read ↗

Targeting PIEZO1 refines macrophage function in atherosclerosisSemantic proximity Read ↗

P311 Curtails Inflammation Through M2-Type Polarization of Macrophages and Potentially via Gut Microbiome ModulationSemantic proximity Read ↗

The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype.Semantic proximity Read ↗

Molecular Pathways Regulating Macrophage Polarization: Implications for AtherosclerosisSemantic proximity Read ↗

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaqueSemantic proximity Read ↗

Integrating the characteristic genes of macrophage pseudotime analysis in single-cell RNA-seq to construct a prediction model of atherosclerosis.Semantic proximity Read ↗

Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of AtherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.