Article

Discrete Transcriptional States Define Biphasic Immune Response and Dynamic CMS Transitions in Colorectal Cancer

2026-02-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Sequential alterations in APC , KRAS , TP53 , and SMAD4 have been proposed as a framework for colorectal cancer progression. Human colorectal cancer datasets have not revealed the biological transitions associated with these mutations. When examining a cohort of TCGA-colorectal tumors grouped as AK (APC/KRAS), AKP (APC/KRAS/TP53), and AKPS (APC/KRAS/TP53/SMAD4) , we ob...

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Literature Corpus work: 34cfa292-4892-55d3-8528-af618d7e3056
DOI: 10.64898/2026.02.03.703597

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