Article

Inference of the Human Polyadenylation Code

2017-04-27

Abstract excerpt

Processing of transcripts at the 3’-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which polyadenylation site is cleaved, alternative polyadenylation enables genes to produce transcript isoforms with different 3’-ends. To facilitate the identification and treatment of disease-causing mutations that affect polyadenylation and to understand the underlying reg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3dff85b0-fda6-5ab4-bf5f-91e6959fc988
DOI: 10.1101/130591

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inference of the Human Polyadenylation CodeDOI 10.1101/130591Read

Predicting the Impact of cis-Regulatory Variation on Alternative PolyadenylationSemantic proximity Read

Deciphering the Impact of Genetic Variation on Human PolyadenylationSemantic proximity Read

Deciphering the impact of genetic variation on human polyadenylation using APARENT2.Semantic proximity Read

Terminitor: Cleavage Site Prediction Using Deep Learning ModelsSemantic proximity Read

Genome-Wide Analysis Reveals a Role of 3’-untranslated Region Variants Affecting Cleavage and Polyadenylation in Undiagnosed Rare DisordersSemantic proximity Read

PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq dataSemantic proximity Read

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and DiseasesSemantic proximity Read

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersSemantic proximity Read

Improving splice site usage prediction with SPLAIRESemantic proximity Read

Pan-cell-type prediction of splicing patterns from sequence and splicing factor expressionSemantic proximity Read

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read

Predicting <i>Alu</i> exonization in the human genome with a deep learning modelSemantic proximity Read